sample reported significant main effects on alcohol consumption for both of these CRHR1 polymorphisms with confirmation in an older alcohol dependent clinical sample. The potential importance of these findings is underscored by an extensive animal literature (Le et al. 2000; Hansson et al. 2006; Sommer et al. 2008; Heilig & Koob, 2007; Pastor et al. 2008) supporting CRF1 receptor involvement in diverse effects of ethanol including sensitization (Pastor et al. 2008), consumption (Hansson et al. 2006), withdrawal (Sommer et al. 2008), and stress-induced relapse (Le et al. 2000).
