One longitudinal investigation (Blomeyer et al. 2008) recruited as infants a high risk sample enriched for those whose births involved severe obstetric problems or whose families experienced substantial psychosocial adversity. At age 15, these individuals (N=280) completed an assessment that included measures of alcohol consumption and severe stressors experienced during the past three years. The authors found evidence of a significant G × E interaction involving a corticotropin-releasing hormone receptor 1 (CRHR1) polymorphism, rs1876831, and negative life events. Specifically, one or more copies of the minor allele was associated with reduced risk for (any) lifetime history of binge drinking and maximum amount of alcohol consumed per occasion in those who had experienced severe stressors. No evidence of a similar G × E interaction was seen for a second CRHR1 polymorphism, rs242938. A prior examination (Treutlein et al. 2006) of their sample reported significant main effects on alcohol consumption for both of these CRHR1 polymorphisms with confirmation in an older alcohol dependent clinical sample. The potential importance of these findings is underscored by an extensive animal literature (Le et al. 2000;
