In Extended Data Fig. 3, all tracks were taken from the UCSC Genome Browser Human hg19 assembly. SNPs (top 5%) shows the top 5% associated SNPs within the locus and are coloured by their correlation to the top SNP. Genes shows the gene models from GENCODE version 19. Conservation was defined at each base through the phyloP algorithm which assigns scores as −log10 P values under a null hypothesis of neutral evolution calculated from pre-computed genomic alignment of 100 vertebrate species49. Conserved sites are assigned positive scores, while faster-than-neutral evolving sites are given negative scores. TFBS conserved shows computationally predicted transcription factor binding sites using the Transfac Matrix Database (v.7.0) found in human, mouse and rat. Brain histone (1.3 year) and brain histone (68 year) show maps of histone trimethylation at histoneH3 Lys 4 (H3K4me3), an epigenetic mark for transcriptional activation, measured by ChIP-seq. These measurements were made in neuronal nuclei (NeuN+) collected from prefrontal cortex of post-mortem human brain50. CpG methylation was generated using meth-ylated DNA immunoprecipitation and sequencing from postmortem human frontal cortex of a 57-year-old male51. DNaseI
