activation, measured by ChIP-seq. These measurements were made in neuronal nuclei (NeuN+) collected from prefrontal cortex of post-mortem human brain50. CpG methylation was generated using meth-ylated DNA immunoprecipitation and sequencing from postmortem human frontal cortex of a 57-year-old male51. DNaseI hypersens displays DNaseI hypersensitivity, evidence of open chromatin, which was evaluated in postmortem human frontal cerebrum from three donors (age 22–35), through the ENCODE consortium52. Finally, hES Chrom State gives the predicted chromatin states based on computational integration of ChIP-seq data for nine chromatin marks in H1 human embryonic stem cell lines derived in the ENCODE consortium53.
