In recent years, the comprehensive evaluation of complement function has shown that the complement system not only plays a traditional role in the immune process but also participates in a variety of important physiological functions, such as lipid metabolism, the inflammatory response, coagulation, angiogenesis, and tissue repair [2,10,16-20]. A growing number of studies have revealed that the complement system also plays essential roles in the progress of alcoholic liver disease (ALD) [21-23]. In this mini-review, we used five search engines, that is, MEDLINE, PubMed, EMBASE, Web of Science, and Biosos Preview, and we screened out 218 papers in this field. We will discuss the recent findings on the role of complement activation and regulation and oxidative stress in the progression of ALD, which might help us to better understand the pathogenesis of ALD and provide some novel potential therapeutic strategy for ALD.
