Bin D (tagged by rs2869046 in Europeans) includes 15 SNPs correlated (r2≥0.7) in the European ancestry reference sample, which was partitioned into 7 sub-bins in Asians and 7 sub-bins in African Americans. We had adequate coverage to test 2 of these 7 sub-bins in Asian samples and 3 of the 7 sub-bins in African American samples. We found no evidence of association between bin D and heavy smoking in European ancestry data, or across populations in single SNP or conditional association analyses (p>0.1). The meta-analyzed genetic associations between available sub-bins and heavy smoking conditional and single SNP associations are shown in Tables S5 and S8. All bins were tested in secondary analyses using the 4 level phenotype measured by cigarettes per day and results were similar.
