Neither the Asian nor African American populations provide strong evidence of association with heavy smoking in any tested sub-bin in bin C under conditional association tests (all p>0.01). In the Asian data, the strongest single SNP signal was the sub-bin tagged by rs6495308 (OR=0.83, 95%C.I.= 0.72–0.96, p=9.8×10−3). In the African American data, there was no evidence of consistent association in either single SNP or conditional analyses (p>0.01) for the sub-bin tagged by rs6495308 or any other sub-bin. The meta-analyzed conditional and single SNP associations between tested sub-bins and heavy smoking are shown in Tables S4 and S7.