Bin C (tagged by rs6495308, rs2036534, rs7163730, rs9788682, rs684513, and rs578776 in Europeans) includes 82 SNPs correlated (r2≥0.7) in the European ancestry reference sample, which was partitioned into 24 sub-bins in Asian and 26 sub-bins in African American reference samples. We had adequate coverage to test 12 of these 24 sub-bins in Asian samples and 19 of these 26 sub-bins in African American samples. Consistent with the previous studies [Liu, et al. 2010; Saccone, et al. 2010; TAG 2010; Thorgeirsson, et al. 2010], in European ancestry samples there is an association between heavy smoking and bin C (OR=0.79, 95% C.I.=0.72–0.86, p= 2.5×10−7) in association tests conditioning on rs16969968, as well as an association in a single SNP analysis (OR=0.77, 95% C.I.=0.71–0.83, p= 4.0×10−11).
