B, with the strongest result for the sub-bin tagged by rs514743 (OR=1.30, 95% C.I.= 1.07–1.58, p=9.7×10−3), which is similar to the single SNP test (OR=1.28, 95% C.I.=1.05–1.56, p=0.014). In African American subjects, there is a trend of association for the same sub-bin in conditional association (OR=1.16, 95%C.I.=0.99–1.36, p=0.064) (Table 3), compared to the single SNP association (OR=1.05, 95%C.I.=0.96–1.15, p=0.24). Thus, we found evidence of association in the Asian samples consistent with the association observed in the samples of European ancestry, but only a trend toward association in the African American subjects. The meta-analyzed conditional and single SNP associations between these constituent sub-bins and heavy smoking are shown in Tables S3 and S6.
