Bin B (tagged by rs588765 and rs880395 in Europeans) includes 111 SNPs correlated (r2≥0.7) in the European ancestry reference sample, which was partitioned into 39 sub-bins in Asian and 37 sub-bins in African American ancestry reference samples. We had adequate coverage to test 10 of these 39 sub-bins in Asian samples and 22 of these 37 sub-bins in African American samples. Consistent with the previous report [Saccone, et al. 2010] which used some of these same data (see Table S1 for the overlap, which involves only European-ancestry samples), we find that in European ancestry samples, bin B is associated (OR=1.27, 95%C.I.=1.16–1.38, p=8.7×10−8) with heavy smoking in conditional analyses with rs16969968; bin B is not associated in single SNP analyses (OR=1.0, 95%C.I.=0.94–1.07, p=0.99). In Asian samples, testing for SNP association conditioning on rs16969968 show an association between heavy smoking and bin B, with the strongest result for the sub-bin tagged by rs514743 (OR=1.30, 95% C.I.= 1.07–1.58, p=9.7×10−3), which is similar to the single SNP test (OR=1.28, 95% C.I.=1.05–1.56, p=0.014). In African American subjects, there is a trend of association for the
