did not address the possibility that clinical sequencing may be ordered by specialists who may not feel comfortable discussing incidental findings pertaining to another organ system, thus generating additional consultations and medical costs. We elected not to consider questions of data ownership or the legal ramifications of returning or withholding raw sequencing results from families that request these. We also did not address issues of patents in making these recommendations or any of the issues associated with duty to recontact ordering clinicians (or patients) and update the interpretation of their incidental findings.31 We have not addressed the implications of including incidental findings in laboratory reports that will become part of the patient’s health record and the potential for discrimination that could arise from this circumstance. We recognize that laboratories that adopt these recommendations may add significant costs to at least some of their sequencing reports with primer design and Sanger confirmation of positive findings, evidence review, report generation and sign-out. We do not know the implications that this may have on reimbursement for clinical sequencing.
