The Working Group elected not to address a number of issues related to incidental findings in clinical sequencing. Conditions that were part of routine newborn screening (NBS) were excluded as they have their own assessment criteria and are applied in a specific public health framework. Similarly, these recommendations address incidental findings sought and reported during clinical sequencing for a specific clinical indication but do not address preconception sequencing, prenatal sequencing, newborn sequencing or sequencing of healthy children and adults. In particular, the issues associated with genomic sequencing in healthy individuals of any age will become increasingly salient as costs decline and informatics interpretation algorithms improve, but the value of population screening for prevention and health promotion raises complex questions of potential benefits as well as downstream risks and costs that will need considerably more data to resolve.27–30 We acknowledged but did not address the possibility that clinical sequencing may be ordered by specialists who may not feel comfortable discussing incidental findings pertaining to another organ system, thus generating additional consultations and medical costs. We elected not to consider questions of
