Here, we systemically investigated cell type enrichment in an extensive set of brain-related phenotypes by integrating mouse scRNA brain data from the Karolinska Institute (KI) and 10x Genomics with summary statistics from 42 phenotypes related to neuropsychiatry, SUDs, and brain-related behavior. Our goals were to perform cell type enrichment for a more comprehensive set of brain-related traits than previously studied and to assess consistency in results across a wider array of methods. We went beyond previous studies by systematically performing cell type enrichment analyses using the most recent releases of different methods that rely on different assumptions and algorithms, i.e., LDSC, MAGMA v1.08, Data-driven Expression Prioritized Integration for Complex Traits (DEPICT), and Functional Mapping and Annotation (FUMA). We found evidence for a subset of neuronal cell types being consistently implicated in several, but not all psychiatric disorders, while non-neuronal cell types seem less implicated.
