Our goals were to identify salient cell types that are implicated in more brain-related traits than previously studied and to assess consistency in results across methods. Brain-related GWAS summary statistics from predominantly European samples were obtained from publicly available sources. A total of 41 summary statistics from brain-related phenotypes (Table 1, Table S1) were obtained, among which 11 psychiatric disorders (486,142 cases and 1,002,695 controls), 11 neurological disorders (186,171 cases and 2,278,970 controls), and 8 substance use disorders (case/control: 11,569 cases and 34,999; cohorts with continuous substance use data: n = 3,683,037). All psychiatric and neurological disorders for which summary statistics were available had also been included in the Brainstorm project [3]. Substance use disorders were added because of the high comorbidity [12, 13] and genetic covariance [14] with psychiatric traits. Eleven well-powered (n > 250,000) brain-related behavioral/quantitative phenotypes (n = 4,166,895) were additionally selected. Because of the association between BMI and brain structure, we considered BMI a brain-related trait [15]. Finally, to discriminate cell types that were specific to the brain, height (n = 693,529) was included as a
