= 4,166,895) were additionally selected. Because of the association between BMI and brain structure, we considered BMI a brain-related trait [15]. Finally, to discriminate cell types that were specific to the brain, height (n = 693,529) was included as a non-brain-related anthropomorphic trait.Table 1Phenotype descriptions.PhenotypeCasesControlsTotal number of participantsSourceAncestryPsychiatric disordersAttention-deficit/hyperactivity disorder (ADHD)19,09934,19453,293PGCEuropeanAnorexia nervosa (AN)16,99255,52572,517PGCEuropeanAnxiety disorders701614,74521,761ANGSTEuropeanAutism spectrum disorder (ASD)18,38227,96946,351PGCEuropeanBipolar disorder (BIP)20,35231,35851,710PGCEuropeanCross disorders162,151a276,846a438,997aPGCEuropeanMajor depressive disorder (MDD)170,756329,443500,199PGCEuropeanObsessive-compulsive disorder (OCD)268870379725PGCEuropeanPost-traumatic stress disorder23,212151,447174,659PGCEuropeanSchizophrenia (SCZ)40,67564,643105,318PGCEuropeanTourette syndrome4819948814,307PGCEuropeanSubstance use disordersAlcohol useN/AN/A121,604PGCEuropeanAlcohol dependence11,56934,99946,568PGCEuropeanDrinks per weekN/AN/A941,280GSCANEuropeanCannabis useN/AN/A162,082PGCEuropeanAge smoking initiationN/AN/A341,427GSCANEuropeanEver smoked regularlyN/AN/A1,232,091GSCANEuropeanCigarettes per dayN/AN/A337,334GSCANEuropeanSmoking cessationN/AN/A547,219GSCANEuropeanNeurological disordersAmyotrophic lateral sclerosis20,80659,80480,610AVSEuropeanAlzheimer’s disease71,880383,378455,258PGCEuropeanEpilepsy15,21229,67744,889ILAEMulti-ancestryGeneralized epilepsy3769b29,677b33,446bILAEMulti-ancestryFocal epilepsy9671b29,677b39,348bILAEMulti-ancestryStroke40,585406,111446,696MEGASTROKEEuropeanIschemic stroke34,217b406,111b440,328bMEGASTROKEEuropeanLarge artery stroke4373b406,111b410,484bMEGASTROKEEuropeanCardioembolic stroke7193b406,111b413,304bMEGASTROKEEuropeanSmall vessel stroke5386b406,111b411,497bMEGASTROKEEuropeanParkinson’s disease37,6881,400,0001,437,688IPDGC-PDWBS-SGPDEuropeanBehavioral/quantitativeBody mass index (BMI)N/AN/A681,275GIANTEuropeanChronotypeN/AN/A449,734SDKPEuropeanExcessive daytime sleepinessN/AN/A452,071SDKPEuropeanSleep durationN/AN/A446,118SDKPEuropeanShort sleep duration106,192b305,742b411,934bSDKPEuropeanLong sleep duration34,184b305,742b339,926bSDKPEuropeanInsomniaN/AN/A453,379SDKPEuropeanIntelligenceN/AN/A269,867CTGLABEuropeanEducational attainmentN/AN/A766,345SSGACEuropeanCognitive performanceN/AN/A257,828SSGACEuropeanNeuroticismN/AN/A390,278CTGLABEuropeanNon-brain-related controlHeightN/AN/A693,529GIANTEuropeanTotal683,8823,316,66412,544,007Detailed descriptions, including references, are listed in Table S1.PGC Psychiatric Genomics Consortium; ANGST Anxiety Neuro Genetics STudy, GSCAN GWAS and Sequencing Consortium of Alcohol and Nicotine use, AVS ALS Variant Server, ILAE International League Against Epilepsy, IPDGC International Parkinson’s Disease Genomics Consortium, SGPD Systems genomics of Parkinson’s disease consortium, PDWBS Parkinson’s disease web based study, SDKP Sleep Disorder Knowledge Portal, CTGLAB Complex Traits Genetics Lab, SSGAC Social Science Genetic Association Consortium.aMay include sample overlap with AN, ADHD, ASD, BIP, MDD, OCD, SCZ, and Tourette syndrome.bSample count of a phenotype that is part
