Chunk #161 — V. “Generalization” of selected genome wide association results between related disorders and phenotypes — H. Alzheimer’s disease (Samples 17, 18) vs substance dependence (Samples 1, 2) genes

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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Data from the overlapping Alzheimer’s disease datasets also overlaps significantly data from the overlapping NIDA addiction vulnerability samples (Samples 1 and 2) [12]. None of 100,000 Monte Carlo simulation trials identifies as many overlapping genes as those identified by these true datasets (Monte Carlo p < 0.00001). These comparisons thus strongly support the “transitive” genetic overlaps between addiction, cognitive function/brain volume and AD based on pleiotropic effects of variants in a number of genes.