Chunk #160 — V. “Generalization” of selected genome wide association results between related disorders and phenotypes — G. Alzheimer’s disease (Samples 17, 18) vs frontal brain volume (Sample 10) genes

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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These overlapping AD datasets overlap significantly with the dataset for frontal brain volume (Uhl et al, submitted). None of 100,000 Monte Carlo simulation trials identifies as many overlapping genes as those identified by these true datasets (Monte Carlo p < 0.00001). Pleiotropic effects of variants in a number of genes are thus likely to influence both AD and frontal brain volume.