Chunk #159 — V. “Generalization” of selected genome wide association results between related disorders and phenotypes — F. Alzheimer’s disease (Samples 17, 18) vs cognitive function (Samples 15, 16) genes
Each of these overlapping Alzheimer’s disease datasets overlaps significantly with each of datasets for cognitive function. None of 100,000 Monte Carlo simulation trials identifies as many overlapping genes as those identified by these true datasets (Monte Carlo p < 0.00001) (Uhl et al, submitted). These comparisons thus strongly support generalization of the observations that we have made in studying general cognitive ability to vulnerability to AD. Pleiotropic effects of variants in a number of genes are thus likely to influence both cognitive ability and AD.
