Chunk #158 — V. “Generalization” of selected genome wide association results between related disorders and phenotypes — E. Frontal brain volume (Samples 10, 11) vs cognitive function (Samples 15, 16) genes

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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Nineteen genes identified by clustered nominally positive SNPs for frontal lobe volume in the NHLBI dataset are also identified by clustered nominally-positive SNPs from each of the two genome wide association assessments for cognitive function. Such overlap was identified by chance in only 212 of 100,000 Monte Carlo simulation trials that correct for repeated comparisons (p < 0.00212). One of these genes, CLSTN2, was also identified in a genome wide association study of individual differences in memory function [154].