The variant with the next smallest P value in the Caucasians was in the T gene that encodes a transcription factor, the T protein, required for posterior mesoderm differentiation and axial development (Edwards et al., 1996). A variant in the T gene (TIVS7-2) has been reported to be associated with neural tube defects (Morrison et al., 1996, Shields et al., 2000, Jensen et al., 2004).
