Three variants in close proximity in the RIMS2 gene were found in the 500 variants with the smallest P values in the Caucasian group. RIMS2 codes for three isozymes, RIM2α, RIM2β, and RIM2γ, members of the RIM family of Rab3-interacting molecules (Wang and Sudhof, 2003). RIMs are found in the active zone of presynaptic nerve terminals, the sites on the plasma membrane where synaptic vesicle exocytosis occurs (Wang et al., 2000).
