Significant effects of age emerged with regard to internetwork but not intranetwork connectivity when examining functional connectivity indices as a function of age, sex, and family history group (Figure 2). Specifically, spatial maps did not suggest differences in intranetwork connectivity with participant age after applying FDR correction. However, there were significant differences in internetwork connectivity between the younger (age 13 – 14 years) and older (age 17 – 18 years) participants. As shown in Figure 2, the group 17 to 18 years of age showed higher connectivity among several different components. For instance, the auditory components had stronger connectivity to various networks including executive, frontal, sensorimotor, and visual components. In addition, sensorimotor components were strongly connected with visual components. Finally, executive control components showed stronger connectivity with visual and frontal components. There were some cases in which the group 13 to 14 years of age had stronger connectivity, primarily between cerebellum components and other brain regions.
