Pair-wise cross-disorder polygene analysisWe derived polygene risk scores for each disorder (discovery sets) and applied them sequentially to the remaining disorders (target sets). Results are grouped by each discovery set. Each pair is shown on the x-axis and the proportion of variance explained for the target disorder (estimated via Nagelkerke’s pseudo R2) on the y-axis. For purposes of illustration, three pT cutoffs are shown, but appendix p 62 shows the proportion of variance results for a broader range of cutoffs. pT=training-set p value (used to select training set SNPs). Significance of results: a=p<0·05; b=p<10−4; c=p<10−8; d=p<1012; e=p<10−16; f=p<10−50. ADHD=attention deficit-hyperactivity disorder. ASD=autism spectrum disorders. BPD=bipolar disorder. MDD=major depressive disorder.
