Other mouse genotype combinations have also been used to map QTLs for ethanol consumption and have provided strong or suggestive evidence for the same regions and for additional regions (Bachmanov et al. 2002; Bice et al. 2006; Gill and Deitrich 1998; Gill and Boyle 2005). There has also been QTL mapping accomplished for ethanol consumption using rats (Bice et al. 1998; Carr et al. 1998, 2003; Foroud et al. 2003; Terenina-Rigaldie et al. 2003b). In one study, following a QTL search in an F2 cross of low (Wistar-Kyoto; WKY) and high (High-Ethanol Preferring; HEP) alcohol consuming lines, a region of rat chromosome 4 was genotyped and rats with alleles from the HEP or WKY lines were each interbred. Analysis of offspring ethanol drinking data confirmed the presence of a QTL that influences ethanol consumption on rat chromosome 4. The same or a linked gene(s) in the same region also influenced saccharin and quinine intake, such that rats with the high ethanol preference genotype consumed more of both tastants (Terenina-Rigaldie et al. 2003a). A chromosome 4 QTL was also found in
