As shown in Table 3, posttraumatic stress disorder (PTSD) was diagnosed most often in Group 4, while antisocial personality disorder (ASPD) had the highest rate in Group 3. At baseline, comorbid bipolar I and II individuals also had a significantly higher rate of alcohol, cocaine, and stimulant dependence compared to non-comorbid Groups 1 to 3. Group 2 (bipolar II + CUD) had a higher rate of sedative and opioid dependence compared to Groups 1, 3, and 4.