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Chunk #14 — Discussion

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Genome-wide association scan in HIV-1-infected individuals identifying variants influencing disease course.
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GWAS may reveal genes that can be considered new targets for drug development. In addition, SNPs strongly associated with HIV-1 disease progression, like the SNPs identified in this study, may be applied in routine diagnostics to predict disease course, or to more accurately estimate if antiviral therapy should be initiated. Indeed, screening for polymorphisms in the human genome that influence the course of infection may ultimately allow for a better fine-tuning of patient management.