From the original 23andMe lead SNPs, only the N6AMT1 locus is not represented in the meta-analysis results at a p-value less than 5×10−6 due to absence of the lead 23andMe SNP in the meta-dataset as well as an absence of significant secondary signals in the region. SNPs in the OLFM4, TMEM161B-MEF2C (two independent SNPs), MEIS2-TMCO5A, and NEGR1 regions reached genome-wide significance in the meta-analysis (p < 5×10−8, correcting for 1.22 million SNPs) (Supplementary Table 2). Regional association plots are shown for these regions in Figure 2. Heritability for the meta-analysis was estimated at h2liab=0.059 and 0.069, for 15 and 25% prevalence.
