Secondly, we culled from the literature rodent drug treatment signatures for experiments that profiled frontal or prefrontal cortex. To ensure higher quality, we required the study to be published after 2005. In total, we curated 11 gene signatures from 7 rodent studies comparing antipsychotic-treated animals to vehicle-treated controls79–85. Nine of the 11 gene signatures were represented by orthologs that were expressed in our study. In total (including the unpublished data described above), 10 rodent gene signatures were tested.
