Using the independent rodent datasets, we found overall similar results as that in the monkeys, with some overlaps of genes impacted by drugs and associated with disease, but with opposite directions of effect on gene expression. Specifically, using the KS test for enrichment, none of the gene signatures were strictly significant after Bonferroni correction (Pbonferroni > 0.05), though two signatures were significantly less concordant than expected by chance after multiple test correction (Pbonferroni = 0.01 and 0.01, Supplementary Table 2B). However, we identified a set of 21 genes that appeared in 4 or more of the gene signatures; 16 of these genes were represented by orthologs in our normalized data, and 8 showed concordant direction in all 4 studies. A one-sided test of enrichment for these “most represented” genes showed a non-significant trend towards enrichment (p = 0.061), with one gene from the signature significant in the CMC DLPFC data at FDR ≤ 5% (ATRX, FDR = 4.5%). Sets of genes that appeared in 3 or more studies, or 2 or more studies, also did not reach statistical significance but
