gene from the signature significant in the CMC DLPFC data at FDR ≤ 5% (ATRX, FDR = 4.5%). Sets of genes that appeared in 3 or more studies, or 2 or more studies, also did not reach statistical significance but did show a trend for overlap (P = 0.084 and 0.071, respectively). However, for each of these gene signatures, the direction of effect was significantly less concordant than expected by chance (1 of 8 [P = 0.004], 10 of 55, and 122 of 388 for those in ≥4 studies, ≥3 studies, and ≥2 studies, respectively).
