The assessment includes other psychophysiological procedures that are thought to tap mechanisms involved with the development of substance use disorders. These assessments include measures of smooth pursuit and antisaccade eye tracking, working memory, ANS habituation, ANS reactivity in anticipation of a stressor, and the emotional modulation of the startle eye-blink response. Because functioning of anterior brain structures may be particularly relevant to understanding the effects of adolescent-onset substance abuse, we have added new measures of brain function likely to be sensitive to the effects of substance misuse at the age-20 follow-up.
