respond to ethanol exposure. A notable contribution of COGA's family design has been to disentangle antecedents of, and predisposition to AUD from its sequelae. By characterizing brain and behavior in offspring from families enriched for AUD liability—both genetic and environmental—prior to the onset of maladaptive drinking behaviors, COGA data have shown the importance of precursors of AUD in a neurobehavioral framework (e.g., References 23, 34, 70, 71, 72). COGA data have validated the 3‐stage neurobiological model 73 of AUD and added to conceptualizations of related multi‐modal assessments (e.g., Reference 74) while also extending them by identifying novel contributors to “exiting” the cycle of AUD towards remission and recovery, amplifying the role of familial liability (e.g., References 23, 31, 33, 75).
