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Chunk #18 — Methods — Data analysis — Cross-sectional genetic analyses

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Stable genetic effects on symptoms of alcohol abuse and dependence from adolescence into early adulthood.
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The decision to fit an ACE or ADE model was based on the correlation structure for a particular age group. If the correlation for MZ twins was smaller than twice the correlation for DZ twins, an ACE model was fitted. If the MZ correlation was more than twice the DZ correlation, the ADE model was fitted to the data. The importance of additive genetic, non-additive genetic and shared environmental factors was tested by dropping the a, d or c parameter from the model and comparing the fit of the restricted model with that of the full model using the likelihood ratio test.