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Chunk #19 — Methods — Data analysis — Longitudinal genetic analyses

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Stable genetic effects on symptoms of alcohol abuse and dependence from adolescence into early adulthood.
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The change in genetic and environmental influences on symptoms of AAD, and specifically whether genetic influences could be best described by the developmentally dynamic or by the developmentally stable hypothesis, was explored by modeling the data in a longitudinal ACE model. The longitudinal model, which examines the cross-age correlations as well as the within-age correlations, has more power to discriminate between additive genetic and shared environmental factors than the cross-sectional models, which only examine the within-age correlations. In the longitudinal model, one threshold (six in total) and one deviation from the threshold for females (six in total) were estimated in each age group.