To assess the correspondence between definition of a drug abuse case used here (past 30 day injection use of an illicit drug, plus use of an illicit drug 10 or more times in the past 30 days) and the phenotype of any DSM-IV drug abuse/dependence, we analyzed data from the 2008 through 2012 National Surveys on Drug Use and Health (NSDUHs). Eighty-seven percent of those who mirrored our study case criteria (unweighted N=225) met a diagnosis of DSM-IV abuse/dependence for any illicit drug in the past 12 months (see Supplemental Information and Table S1). Thus, it is very likely that the drug abuse cases from UHS have clinically important abuse/dependence and that any findings from this study should be applicable to and testable in cohorts with clinical diagnostic phenotypes.
