DEG sets were next assessed for enrichment of gene functions (FDR adjusted for multiple testing, both here and for enrichment analysis). To do so, the 904 (global), 29 (caudate), and 216 (nucleus accumbens) DEG sets were queried against the MSigDB C2 curation, the C5 curation (GO sets), and the Hallmark gene sets. The global DEG were significantly enriched for 13 Reactome, 32 GO, and 5 Hallmark gene sets. DEG from the nucleus accumbens were enriched for one Hallmark gene set, and DEG from the caudate were enriched for one REACTOME and two GO gene sets after correction for multiple testing (Tables S3a/b).
