For the top identified 6 genes/loci (rs11128951 near SGOL1, rs17144687 near DTWD2, rs12108602 near NDST4, KCNB2, rs2677485 near NR4A2 and DDC) by the meta-analysis and GWA analysis, we selected 282 SNPs from the OZALC dataset to perform a replication analysis of our results. For each SNP in meta-analysis which is not within a known gene, we chose 20 flanking SNPs in the OZALC dataset while we included all the markers in each of the genes (KCNB2, DDC and GRB10) from the OZALC sample. Based on the QVALUE, when the p-value cutoff is 0.05, 20 out of 282 SNPs were associated with MaxDrinks in the OZALC sample, with FDR of 0.54 (Table 4). Three genes (NDST4, KCNB2 and DTWD2) were confirmed to be associated with MaxDrinks in the replication study by testing the flanking SNPs in the OZALC family sample (p < 0.05). In Table 4, twelve flanking SNPs that located near NR4A2 at 2q24.1 have been replicated in the family sample while the top hit was rs1402071 (p = 0.0019). In addition, one SNP rs7624305 near SGOL1 and one SNP
