In association studies, the evaluation of false-positive results is an important issue. In this study, VAND was used initially to identify the associations, and VAANX was used to confirm the associations. For VAND, we performed simple and sex-stratified analyses for all 10 SNPs. We also performed sex-stratified haplotype analyses for several combinations. The effective number of tests was 23. Based on this calculation, only rs1049353 survives multiple testing correction for association with ND. For haplotype tests, associations with ND remain significant for both the global and haplotype tests for all combinations. In the replication panel, we performed 11 tests (8 equivalent independent tests for sex-stratified single-marker tests and 3 sex-stratified haplotype tests). Although rs2023239 showed nominal association with SI in the same allele and same sex as observed in the VAND sample and rs6928499 showed a trend in the same allele and sex, none of them could survive correction for multiple comparison. In haplotype analyses, although combinations 7-9-10 and 5-7-9-10 had associations with the FTND score in the same haplotypes and sex, only haplotype 1-1-2 of the combination 7-9-10 could
