allele and sex, none of them could survive correction for multiple comparison. In haplotype analyses, although combinations 7-9-10 and 5-7-9-10 had associations with the FTND score in the same haplotypes and sex, only haplotype 1-1-2 of the combination 7-9-10 could be considered significant. Considering the replication criteria proposed in the recent literature,61,62 in which a replication could be made at the level of a single marker, a haplotype, or a gene, we could argue that we have replicated the association with ND at haplotype 1-1-2 for combination 7-9-10. Based on the simulations reported by Sullivan,62 replications at the same marker, same allele, and same sex or at the same marker combination, same haplotype, and same sex had the lowest false-positive rate. Accordingly, we could conclude that CNR1 is likely associated with ND. The association with SI, however, is less clear, and additional studies will be needed to clarify this issue.
