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Chunk #28 — Results

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A large-scale genome-wide association study meta-analysis of cannabis use disorder.
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unrel OR (SE)PGC EUR unrel p valuePGC EUR comp Z scorePGC EUR comp p valueEUR meta-analysis OR (SE)*EUR meta-analysis p value*Transancestral Z score†Transancestral p value†Chromosome 7114 116 881rs7783012A1·10 (0·03)5·32 × 10−41·09 (0·03)2·58 × 10−31·11 (0·03)9·56 × 10−53·475·22 × 10−41·11 (0·02)1·84 × 10−95·972·43 × 10−9Chromosome 827 432 062rs4732724‡C0·90 (0·03)3·03 × 10−40·84 (0·03)5·73 × 10−80·98 (0·04)0·616−1·910·0560·89 (0·02)6·46 × 10−9−5·952·64 × 10−9comp=complete meta-analysis (including related individuals and summary statistic cohorts). EUR=European ancestry. OR=odds ratio. PGC=Psychiatric Genomics Consortium. SNP=single nucleotide polymorphism. unrel=unrelated genotyped meta-analysis.*Complete deCODE, iPSYCH, and PGC EUR meta-analysis (excluding related individuals and summary statistic cohorts in the PGC).†Transancestral meta-analysis with deCODE, iPSYCH, and PGC samples (including related individuals and summary statistic cohorts).‡SNP was only present in half of the PGC samples.