We identified two genome-wide significant loci in the transancestral meta-analysis of cannabis use disorder (African and European ancestries, 20 916 cases, 363 116 controls; appendix pp 17, 20). These loci were significant in the European ancestry meta-analysis but did not reach significance in the much smaller African ancestry analysis (17 068 cases, 357 219 controls vs 3848 cases, 5897 controls; table 2). The lead SNPs were rs4732724 on chromosome 8 (ptransancestral=2·64 × 10−9, pEuropean=6·46 × 10−9, pAfrican=0·70) and rs7783012 on chromosome 7 (ptransancestral=2·43 × 10−9, pEuropean=1·84 × 10−9, pAfrican=0·09), with the same direction of effect observed for both ancestries. No additional ancestry-specific loci were observed.Table 2Association statistics for the lead genome-wide significant SNPs across each of the three primary samples (deCODE, iPSYCH, PGC) in the European ancestry and transancestral meta-analysesPositionSNPEffect alleledeCODE OR (SE)deCODE p valueiPSYCH OR (SE)iPYSCH p valuePGC EUR unrel OR (SE)PGC EUR unrel p valuePGC EUR comp Z scorePGC EUR comp p valueEUR meta-analysis OR (SE)*EUR meta-analysis p value*Transancestral Z score†Transancestral p value†Chromosome 7114 116 881rs7783012A1·10 (0·03)5·32 × 10−41·09 (0·03)2·58 × 10−31·11 (0·03)9·56 × 10−53·475·22 × 10−41·11 (0·02)1·84
