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Chunk #53 — Discussion — Other hypotheses

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Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.
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Most of the additional exploratory analyses were unrevealing, including examination of proteins known to interact with PCLO, genotype imputation, comparison of GWAS findings with MDD candidate genes from the literature and gene expression changes in the brain in cases with MDD, and alternative genetic models, phenotype definitions, and sex-specific analyses.