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Chunk #54 — Discussion — Other hypotheses

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Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.
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We searched the SLEP compendium of psychiatric genetics findings (101) to attempt to discover overlap of our findings with those reported in the literature. First, with reference to a meta-analysis of microarray studies on the Stanley brain bank MDD and control samples, expression of CFLAR and MARCH3 were increased and LST1 and HLA-B were decreased in MDD post-mortem frontal cortex. These regions ranked 9, 232, 267, and 432 in the NESDA/NTR GWAS. Second, we looked for convergence of our findings with other GWAS of psychiatric disorders. Notable genomic locations of overlap of the top 480 regions in the present GWAS were found with GWAS for ADHD (ITIH1, S Faraone, personal communication), the WTCCC GWAS for bipolar disorder (SHFM1 and UGT2B4) (102), and a bipolar GWAS that used DNA pooling (GRM7 and DGKH) (70). Third, we looked at the minimum p-values in our study for genes that met or nearly achieved genomewide significance: the minimum p-values in our study for MAMDC1 (103) was 0.004, 0.03 for ZNF804A (104), 0.002 in ANK3 (105), and 0.03 in CACNA1C (105). These overlaps are intriguing