ontology terms is assisted by auto-completion, and we also provide the possibility of using ontologies to browse search results. Viewing of result sets, as well as database entries, is configurable. The site has a simple and consistent URL scheme and all searches can be bookmarked to be repeated at a later time. The home page features a site-tour as a quick introduction for novice users. In response to user requests for various downloadable data sets (e.g. all reviewed human entries in FASTA format), we have removed all download limits to allow this functionality by directly querying the website. However, large downloads are given low priority in order to ensure that they do not interfere with interactive queries, and they can therefore be slow compared to downloads from the UniProt FTP server. We therefore recommend downloading complete datasets from ftp.uniprot.org/pub/databases. The website offers various download formats which depend on the chosen dataset (e.g. plain text, XML, RDF, FASTA, GFF for UniProtKB). The columns of result tables can be configured for customized downloads in tab-delimited or Excel format. All data is available in RDF (http://www.w3.org/RDF/), a W3C standard for publishing data on the Semantic Web. All search results can be retrieved as