In the mPFC 11,579 genes were detected, among which 638 (5.5%) (Table 1) were differentially expressed (Supplemental Table 1). As in the vHip, many of the differentially expressed genes were expressed at low levels (Supplemental Figure 2), and only 10% of the differentially expressed genes changed by > 1.5 fold (Figure 1). In contrast to the vHip, only 35% of the differentially expressed genes in the mPFC were lower in the binge drinkers (Table 1). Astrocyte enriched genes had a significantly larger percentage of genes decreased (62%. p = 1.4e-7) than did neurons (25%) or oligodendrocytes (36%). Genes with large fold changes in the mPFC include Atf3, Cyr61, Apold1, Btg2, and Npas4 (Table 4) all increased; these genes are also increased in the vHip. Also increased in the mPFC are Ier2, Gadd45g and Klf4 (Table 4).
