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Chunk #3 — Structural MRI — Structural MRI Findings in Alcoholism-Related Brain Diseases — Wernicke-Korsakoff Syndrome

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Alcohol's Effects on the Brain: Neuroimaging Results in Humans and Animal Models.
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a lesser but significant volume deficit in uncomplicated alcoholics (Sheedy et al. 1999; Sullivan et al. 1999b; but see Shear et al. 1996; Victor et al. 1989). In contrast with early MR studies suggesting that KS affects the mammillary bodies while sparing the hippocampi (Squire et al. 1990), more recent work demonstrates hippocampal volume deficits in KS (Sullivan and Marsh 2003). Other regions affected by KS are the thalamus, orbitofrontal cortex (Jernigan et al. 1991b), cerebellum, and pons (Zahr et al. 2009).