Overall, 14 out of 18 included studies contributed to the identified clusters of convergence. Most of them contributed to C1 (eight studies), followed by C2 (seven studies), C3 (five studies), and C4 (four studies). The contributing studies as well as the number of contributing foci and their respective WM measures and contrasts are summarized in supplementary Table S3. The convergence of C1–C4 mainly emerges from foci referring to contrasts of reduced WM volume/density or structural integrity (e.g., lower fractional anisotropy (FA) and higher mean-, radial-, or axial diffusivity measures (MD, RD, AD) of WM fiber tracts in AUD patients. Only for C1, one foci refers to an opposite contrast of higher FA values and for C3, one foci refers to a contrast of higher WM volume. One of the contributing studies used a joint independent component analysis (jICA) procedure and did not report the direction of individual effects of the integrated coefficients (FA, MD, RD) [45]. The findings of this study can thus only be interpreted as a change in fiber integrity in AUD. Regarding the robustness of the meta-analytic
