The trans-ancestral discovery meta-analysis of GWAS of AD in 28 cohorts (Table 1; Supplementary Table S1) identified a genome-wide significant (GWS; p < 5E-8) association in the ADH gene cluster on chromosome 4 (Figure 1; Table 2). Examining this locus in each population (Figure 2), rs1229984 in ADH1B was the strongest associated variant from the analysis in EU (z = −7.13, p = 9.8E-13), while rs2066702, also in ADH1B, was the most significant variant in AA (z = −5.98, p = 2.2E-9). Trans-ancestral modelling reinforced the robust effects of rs1229984 and other ADH1B SNPs on liability to AD across inverse-variance weighted, random effects, and Bayesian models (Supplementary Figure S1, Supplementary Table S2).
