in the caudate (Fig. 3C), smaller ependymal cell fractions in the nucleus accumbens (Fig. 3D), and a larger fraction of vascular cells in the OFC of OCD subjects compared to unaffected comparison subjects (Fig. 3B; Table S5). While regional results do not achieve significance after correction for multiple testing, they are consistent with global results. Similar results were obtained using human single nucleus RNA (snRNA) sequencing as our reference dataset44 for deconvolution (Fig. S4 and Tables S6, S7), with an overall reduction in medium spiny neuron fractions (p = 0.001) and an increase in astrocytic fractions (p = 0.01) in the global analysis.
