A recent study by Lisboa and colleagues37 also evaluated DEG in three striatal brain regions from six OCD and eight control subjects. Since two of our study’s brain regions overlapped with theirs (caudate and nucleus accumbens), we compared the DEG sets. Because DEG provided by Lisboa et al. were only a subset of all genes they evaluated (specifically those having an uncorrected p-value <0.01), we evaluated this DEG set and limited our comparison to Ensembl genes. Matching the Lisboa DEG set with results from all transcripts detected in our study (Table S8) produced 541 and 126 genes overlapping across studies for caudate and nucleus accumbens, respectively (Table S9). Despite the relatively small sample size for each study, the correlations of their differential expression in log2 fold change were both substantial: 0.42 (caudate: p < 4.4 × 10−25) and 0.26 (NAc: p < 0.0032) (Table S8).
